What are the classic symptoms of Cushing's syndrome?

Cushing's syndrome is characterized by excessive levels of cortisol in the body, leading to a distinct pattern of symptoms. The classic symptoms include weight gain, which is often noticeable in specific areas like the abdomen and face, leading to the appearance of moon facies. Additionally, fat redistribution can occur, resulting in a buffalo hump—a buildup of fat at the back of the neck and upper back. These features are hallmark signs of Cushing's syndrome and are directly related to the effects of cortisol on metabolism and fat deposition.

In contrast, the other options present symptoms that don't appropriately align with Cushing's syndrome. Weight loss, palpitations, and tremors might suggest hyperthyroid conditions or other issues, while symptoms such as hyperpigmentation, hypotension, and fatigue could be more indicative of adrenal insufficiency rather than excess cortisol. Lastly, jaundice, ascites, and pruritus are typically associated with liver dysfunction or other hepatic conditions, which are not characteristic of Cushing's syndrome. Thus, option B accurately reflects the classical symptoms one would expect in a patient with this condition.