What is the first-line treatment for generalized anxiety disorder?

The first-line treatment for generalized anxiety disorder (GAD) is selective serotonin reuptake inhibitors (SSRIs). SSRIs, such as sertraline or escitalopram, are often favored due to their efficacy in alleviating anxiety symptoms and their favorable safety profile compared to other pharmacologic options. They work by increasing the levels of serotonin in the brain, which is thought to have a good effect on mood and anxiety regulation.

Pharmacotherapy, particularly with SSRIs, is recommended as the initial treatment approach in GAD and can be combined with psychotherapy for a more comprehensive management strategy. SSRIs have been extensively studied and are supported by clinical guidelines as a cornerstone of treatment for anxiety disorders, including GAD.

While cognitive behavioral therapy (CBT) is also an effective treatment option and can be used alone or in conjunction with medication, SSRIs are commonly considered first-line due to their ability to provide relief from symptoms more rapidly and effectively in many patients. Other options, such as buspirone and beta-blockers, are generally considered adjunctive treatments rather than primary therapies for GAD.