What is the first-line treatment for uncomplicated urinary tract infections in women?

The first-line treatment for uncomplicated urinary tract infections (UTIs) in women is nitrofurantoin. This antibiotic is particularly effective for this condition due to its ability to concentrate in the urine, making it highly effective against common uropathogens, especially Escherichia coli, which is the most prevalent cause of uncomplicated UTIs.

Nitrofurantoin is also well-tolerated, has a favorable side effect profile, and is generally preserved as a treatment option to minimize resistance development. The short duration of therapy, often just 5 days, further supports its use as a preferred treatment.

Although other antibiotics mentioned can be effective for UTIs, they may not be as suitable for first-line use in uncomplicated cases due to considerations such as resistance patterns, side effects, or broader-spectrum activity that could contribute to resistance in the community. Therefore, nitrofurantoin remains the recommended choice for uncomplicated UTIs in women.