What is the primary treatment for chronic herpes simplex virus infections?

The primary treatment for chronic herpes simplex virus infections typically involves antiviral medications that can effectively manage and suppress the virus. Acyclovir is a well-established antiviral that directly inhibits the replication of the herpes simplex virus. It works by interfering with the viral DNA synthesis, leading to a decrease in viral load and severity of outbreaks.

While valacyclovir and famciclovir are also effective antiviral agents and have the advantage of potentially less frequent dosing and improved bioavailability, acyclovir remains the cornerstone treatment for many patients due to its long history of use and extensive clinical experience supporting its efficacy and safety in managing chronic herpes infections. Additionally, topical antivirals are usually reserved for localized infections or as adjunctive therapy, rather than as a primary treatment for chronic infections.