Which medication is effective for reducing inflammation in SLE-related pericarditis?

In systemic lupus erythematosus (SLE), pericarditis can occur due to inflammation of the pericardial sac. The primary goal in managing this condition is to reduce inflammation and alleviate symptoms. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are commonly used and effective for treating mild inflammatory pericarditis; however, they may not suffice alone in more severe cases.

Glucocorticoids, or corticosteroids, are powerful anti-inflammatory agents that can be used in conjunction with NSAIDs for moderate to severe inflammation. The combination of ibuprofen and glucocorticoids can provide more effective control of symptoms and inflammation associated with SLE-related pericarditis than either medication alone.

Using a dual approach can help manage patients who do not respond adequately to NSAIDs alone, allowing for the treatment of significant inflammation while minimizing the risk of complications related to both persistent inflammation and the toxicity associated with higher doses of corticosteroids when used alone. Thus, the combination of ibuprofen and glucocorticoids is particularly beneficial in this context, making it the best choice for managing SLE-related pericarditis.