Which medication is known to cause oligohydramnios as a teratogenic effect?

Lisinopril, an ACE inhibitor, is known to be associated with oligohydramnios as a teratogenic effect during pregnancy. Oligohydramnios refers to a reduced amount of amniotic fluid, which can occur due to fetal renal impairment and decreased urine production. Lisinopril can disrupt the renin-angiotensin system, which is critical for maintaining amniotic fluid levels, especially in the second and third trimesters. This teratogenic effect is particularly concerning during the first trimester when organogenesis occurs and can lead to various complications for both the fetus and the mother.

Other medications listed, while they may have their own risks during pregnancy, are not typically associated with causing oligohydramnios. Metformin is primarily used for managing gestational diabetes and generally doesn't have teratogenic effects related to amniotic fluid levels. Warfarin can cause a range of fetal abnormalities but is not specifically linked to oligohydramnios. Amiodarone is known for its association with thyroid dysfunction and pulmonary issues in the fetus, rather than directly causing oligohydramnios. Thus, the relationship between lisinopril and oligohydramnios makes it the correct answer in this